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《医学前沿(英文)》 2017年 第11卷 第4期 页码 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis B, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA rebound and disease relapse. In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serum HBV RNA is systematically described. The production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBV RNA is found to be a suitable surrogate marker for the activity of intrahepatic covalently closed circular DNA (cccDNA), particularly among patients receiving NA therapy. Therefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBV RNA. In contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integrated HBV DNA fragment, serum HBV RNA, with pregenomic RNA origination, can only be transcribed from cccDNA. Therefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuation. The clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might be implicated as a “para-functional cure,” a status nearly close to the functional cure of chronic hepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with or without anti-HBs seroconversion.
关键词: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Current advances in the elimination of hepatitis B in China by 2030
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading public health challenges in China. Over the last two decades, China has made great progress on the prevention of HBV transmission through national vaccination programs. Zero transmission from mother to infant has been proposed as the current goal. Available anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronic hepatitis B and even requires lifelong treatment. To reduce the costs and improve the efficacy, several trials have been recently conducted in China to optimize the current anti-HBV managements. Novel biomarkers were identified to predict treatment outcomes, and new promising treatment strategies were developed. Reports also indicate that coinfections of HBV with other hepatotropic viruses and human immunodeficiency virus are common in China and cause severe liver diseases, which should be recognized early and treated properly. Work is still needed to eliminate hepatitis B in China by 2030.
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 96-100 doi: 10.1007/s11684-014-0316-4
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN+ pelvic lymph node (PLN) dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B (P<0.05). In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant (P>0.05). The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate (P=0.044). In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant (P=0.048). Cox model analysis of single factor suggested that lymph node status affected the survival rate (P<0.01), which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary.
关键词: ovarian cancer para-aortic lymph node pelvic lymph node
Vincent Froidevaux, Mélanie Decostanzi, Abdelatif Manseri, Sylvain Caillol, Bernard Boutevin, Rémi Auvergne
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 330-339 doi: 10.1007/s11705-020-1929-6
关键词: thiol-ene polymerization self-curing on demand thia-michael addition Diels-Alder maleimide
高金吉
《中国工程科学》 2003年 第5卷 第12期 页码 30-35
按照耗散结构理论,人类与其所创造的装备在本质上是有共性的,在与疾病和与故障的斗争方面也有很多相同或相近之处。在系统论的指导下,将医学科学理论和方法用于装备的故障诊断、预测和防治,有可能逐步形成用工程手段来防治故障的专门用于装备的“医学”——“装备医工程”(PME, plant medicine engineering);讨论了疾病和故障成因及其诊断、病因和故障机理的深层规律、治愈和自愈、治标和治本等共性问题,并就汲取中医的黑箱法和西医白箱法的精髓,创建医工程的水晶箱法进行了探讨;应用上述理论,对当前设备诊断技术研究的若干误区进行了分析。
Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 1-20 doi: 10.1007/s11783-011-0301-y
关键词: functional gene arrays (FGAs) GeoChip microbial communities functional diversity/composition/structure environmental factor ecosystem functioning
Fluorescent probes and functional materials for biomedical applications
《化学科学与工程前沿(英文)》 2022年 第16卷 第10期 页码 1425-1437 doi: 10.1007/s11705-022-2163-1
关键词: fluorescent probes imaging cell biomedicine biomolecules
Phase separation time/temperature dependence of thermoplastics-modified thermosetting systems
ZHANG Xiujuan, XU Yuanze, YI Xiaosu
《化学科学与工程前沿(英文)》 2008年 第2卷 第3期 页码 276-285 doi: 10.1007/s11705-008-0057-5
关键词: separation time-temperature temperature dependency cure-induced separation activation temperature
Zhaoxing HAN, Zhenyao SHEN, Yongwei GONG, Qian HONG
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 119-129 doi: 10.1007/s11783-011-0272-z
关键词: emission trading water functional zone water quality control
A Study of the Functional Mechanism of Petrochemical Engineering Construction Project Management
Ji-ming Wang
《工程管理前沿(英文)》 2014年 第1卷 第2期 页码 129-139 doi: 10.15302/J-FEM-2014020
关键词: petrochemical engineering construction project project management functional mechanism
Effects of functional groups for CO
Chenkai Gu, Yang Liu, Weizhou Wang, Jing Liu, Jianbo Hu
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 437-449 doi: 10.1007/s11705-020-1961-6
关键词: metal-organic frameworks functional groups CO2 capture GCMC DFT
Yi ZHONG, Jian WANG, Yizhi SONG, Yuting LIANG, Guanghe LI
《环境科学与工程前沿(英文)》 2012年 第6卷 第6期 页码 797-805 doi: 10.1007/s11783-012-0405-z
关键词: crude oil-contaminated soil phytoremediation rhizosphere effects rhizobox functional genes
Behavioral methods for the functional assessment of hair cells in zebrafish
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 178-190 doi: 10.1007/s11684-017-0507-x
Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.
关键词: zebrafish (Danio rerio) behavior auditory startle response vestibular-ocular reflex rheotaxis
《化学科学与工程前沿(英文)》 2023年 第17卷 第9期 页码 1221-1230 doi: 10.1007/s11705-023-2298-8
关键词: vanadium redox flow battery functional groups organic additives energy density stability
Kai Cai, Ying Li, Hongbao Shen, Zaizhe Cheng, Shouying Huang, Yue Wang, Xinbin Ma
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 319-329 doi: 10.1007/s11705-020-1957-2
关键词: dimethyl ether carbonylation mechanism heteropolyacids density functional theory
标题 作者 时间 类型 操作
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide analogs
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期刊论文
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
null
期刊论文
Improved “cure on demand” of aromatic bismaleimide with thiol triggered by retro-Diels-Alder reaction
Vincent Froidevaux, Mélanie Decostanzi, Abdelatif Manseri, Sylvain Caillol, Bernard Boutevin, Rémi Auvergne
期刊论文
Development and applications of functional gene microarrays in the analysis of the functional diversity
Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU
期刊论文
Phase separation time/temperature dependence of thermoplastics-modified thermosetting systems
ZHANG Xiujuan, XU Yuanze, YI Xiaosu
期刊论文
Temporal dimension and water quality control in an emission trading scheme based on water environmental functional
Zhaoxing HAN, Zhenyao SHEN, Yongwei GONG, Qian HONG
期刊论文
A Study of the Functional Mechanism of Petrochemical Engineering Construction Project Management
Ji-ming Wang
期刊论文
Microbial community and functional genes in the rhizosphere of alfalfa in crude oil-contaminated soil
Yi ZHONG, Jian WANG, Yizhi SONG, Yuting LIANG, Guanghe LI
期刊论文
Characterization and comparison of organic functional groups effects on electrolyte performance for vanadium
期刊论文